Synthesizing Regularity Exposing Attributes in Large Protein Databases

This thesis describes a system that synthesizes regularity exposing attributes from large protein databases. After processing primary and secondary structure data, this system discovers an amino acid representation that captures what are thought to be the three most important amino acid characteristics (size, charge, and hydrophobicity) for tertiary structure prediction. A neural network trained using this 16 bit representation achieves a performance accuracy on the secondary structure prediction problem that is comparable to the one achieved by a neural network trained using the standard 24 bit amino acid representation. In addition, the thesis describes bounds on secondary structure prediction accuracy, derived using an optimal learning algorithm and the probably approximately correct (PAC) model.

Exploring Bit-Difference for Approximate KNN Search in High-dimensional Databases

In this paper, we develop a novel index structure to support efficient approximate k-nearest neighbor (KNN) query in high-dimensional databases. In high-dimensional spaces, the computational cost of the distance (e.g., Euclidean distance) between two points contributes a dominant portion of the overall query response time for memory processing. To reduce the distance computation, we first propose a structure (BID) using BIt-Difference to answer approximate KNN query. The BID employs one bit to represent each feature vector of point and the number of bit-difference is used to prune the further points. To facilitate real dataset which is typically skewed, we enhance the BID mechanism with clustering, cluster adapted bitcoder and dimensional weight, named the BID⁺. Extensive experiments are conducted to show that our proposed method yields significant performance advantages over the existing index structures on both real life and synthetic high-dimensional datasets.

Fast Contour Matching Using Approximate Earth Mover's Distance

Weighted graph matching is a good way to align a pair of shapes represented by a set of descriptive local features; the set of correspondences produced by the minimum cost of matching features from one shape to the features of the other often reveals how similar the two shapes are. However, due to the complexity of computing the exact minimum cost matching, previous algorithms could only run efficiently when using a limited number of features per shape, and could not scale to perform retrievals from large databases. We present a contour matching algorithm that quickly computes the minimum weight matching between sets of descriptive local features using a recently introduced low-distortion embedding of the Earth Mover's Distance (EMD) into a normed space. Given a novel embedded contour, the nearest neighbors in a database of embedded contours are retrieved in sublinear time via approximate nearest neighbors search. We demonstrate our shape matching method on databases of 10,000 images of human figures and 60,000 images of handwritten digits.

Logging and Recovery in a Highly Concurrent Database

This report addresses the problem of fault tolerance to system failures for database systems that are to run on highly concurrent computers. It assumes that, in general, an application may have a wide distribution in the lifetimes of its transactions. Logging remains the method of choice for ensuring fault tolerance. Generational garbage collection techniques manage the limited disk space reserved for log information; this technique does not require periodic checkpoints and is well suited for applications with a broad range of transaction lifetimes. An arbitrarily large collection of parallel log streams provide the necessary disk bandwidth.